Search Results - nader+mostowfi

Novel (2-oxo-2H-chromen-3-yl) scaffold based carboxamide analogs as potent inhibitors of tau protein fibrils

Small-molecule carboxamides that inhibit and disassemble tau fibrils associated with Alzheimer’s disease Optimized for blood-brain barrier penetration and favorable pharmacokinetic properties Demonstrated efficacy in Alzheimer’s disease brain tissue and cell-based models Abstract USC researchers have developed carboxamide-based small...