Description:
- Research and diagnostic
- Flow cytometry
- Histopathology
Abstract
A USC researcher has generated a murine monoclonal antibody, 58-15. Since the antibody can be used in paraffin embedded tissue sections, it can identify actively cycling cells within a tissue specimen, making it a useful tool for immunopathologic studies on tissues from which prognostic information can be derived for disease states such as cancer.
Benefit
- High specificity
- Works on paraffin embedded tissues
- Able to stain histopathologic tissues and flow cytometric samples
- Able to recognize a new nuclear antigen related to cell proliferation
- Can be used to measure the mitotic activity of cell populations within a tissue specimen
Market Application
The ability to quantitate and identify dividing cells is important in histologically-based tumor classifications. However, only a few monoclonal antibodies are presently available with the specificity to stain histopathlogical tissues and flow cytometric samples.
Other