2994 - Transgenic Mouse Model with Prostate- Specific Expression of Cre Recombinase

• Research tool for studying prostate development and prostatic disease

Abstract

USC researchers have generated a Cre transgenic mouse line that displays strong expression of the Cre gene specifically in the prostate tissue to aid in the study of prostatic diseases. Since the Cre model has expression only in the prostate, crossing between a mouse line with any floxed gene target and this Cre line should yield the desired model of prostate specific deletion of the target gene only after puberty, when the probasin promoter is activated.

Benefit

• Prostate-specific expression of Cre could be utilized to define the role of any target genes in the development of the prostate without interference with normal fetus development, growth and birth

Market Application

Prostate cancer predominantly affects the elderly. It is estimated that roughly 165,000 new cases are diagnosed every year. However, its etiology remains largely unknown, which leads to an unpredictable clinical course.

Publications

Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation. Mech Dev. (2000).