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Background
Heart failure with preserved ejection fraction (HFpEF) due to left ventricular (LV) diastolic dysfunction is a growing clinical challenge. Currently, the gold standard diagnostic method is invasive procedures like cardiac catheterization with direct measurement of LV pressure decay. These invasive methods are costly, time-consuming, and...
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Background
Target engagement quantification is crucial in drug discovery for understanding drug-protein interactions, mechanisms of action, and resistance. Traditional methods like activity-based protein profiling with gel fluorescence, while effective, are limited by low throughput, long processing times, and disruption of native protein functions....
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Background
G-protein-coupled receptors (GPCRs) are pivotal in cell signaling and represent a major target class for drug development. Among them, cannabinoid receptors, especially CB2, play a crucial role in regulating neuroinflammation and immune responses. Current therapeutic options inadequately modulate CB2 activity, limiting effective treatment...
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Unmet Need
Real-time control and edge decision systems often depend on linear or quadratic optimization. Digital solvers can be too slow and energy-intensive for embedded uses such as autonomous vehicle control and medical classification. A practical hardware platform must also remain programmable so it can solve different optimization problems.
USC...
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Unmet Need
RFIC designers need faster ways to develop compact, high-performance circuits for millimeter-wave wireless, radar, and imaging systems. Conventional workflows rely on expert intuition and repeated schematic, layout, and post-layout simulations, limiting the geometries that teams can practically explore.
USC Technology
USC researchers developed...
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Background
Accurate detection of cracks in concrete and pavement infrastructure is critical for maintaining safety and durability, yet traditional manual inspections are labor-intensive and subjective. Deep learning models offer promise but are hindered by the scarcity of large, diverse, and well-annotated datasets. Existing datasets are limited in...
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Market Opportunity
Current energy storage technologies, primarily lithium-ion batteries, face limitations in energy density, safety, and resource availability. Fluoride-ion (F-ion) batteries represent a promising alternative due to their potential for higher energy density and improved safety profiles. However, existing F-ion battery materials often...
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Market Opportunity
Carbon fiber reinforced polymers (CFRPs) are extensively used in aerospace, automotive, and energy sectors due to their exceptional strength-to-weight ratio and durability. However, recycling these materials remains challenging because their polymer matrices are highly cross-linked and difficult to break down. Traditional recycling...
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Market Opportunity
Poly(vinyl chloride) (PVC) is a widely used polymer known for its flexibility, durability, and chemical resistance, but its recycling and modification have long posed challenges. Traditional methods of dechlorination often produce random copolymers, limiting control over the resulting polymer’s properties and reducing material...
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Market Opportunity
Water treatment membranes are essential for processes such as seawater desalination, wastewater treatment, and potable water reuse. Current methods to assess membrane compaction-- like scanning electron microscopy (SEM)—only capture static measurements before and after stress, lacking real-timeinsights. This creates a critical...
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