|
Novel microprotein therapeutic that restores mitochondrial function to address neurodegeneration
Reduces neuroinflammation and improves brain metabolism for broad neuroprotective effects
Demonstrated efficacy in in vitro and in vivo models of neurodegenerative disease
Abstract
USC researchers have identified SHMOOSE, a novel mitochondrial microprotein...
|
|
Small-molecule carboxamides that inhibit and disassemble tau fibrils associated with Alzheimer’s disease
Optimized for blood-brain barrier penetration and favorable pharmacokinetic properties
Demonstrated efficacy in Alzheimer’s disease brain tissue and cell-based models
Abstract
USC researchers have developed carboxamide-based small...
|
|
Background
Modern compression systems use a set of fixed mathematical tools to remove unnecessary information from each video frame. While these tools work well, they treat most video content in the same way and cannot adapt to the unique characteristics of each scene. As video resolutions, frame rates, and streaming demands continue to increase,...
|
|
Background
Thousands of tons of spent nuclear fuel around the world have been locked away in stainless-steel canisters with limited lifetimes and an imminent need of transportation or potential repackaging.
Current inspection tools are
Invasive and costly
Lengthy
Unable to detect critical damage modes
Technology Description
USC researchers...
|
|
Background
Many advanced materials and molecular systems require precise, reversible control over molecular interactions. Applications for responsive materials, biomedical systems and adaptive surfaces need on-demand, localized, and reversible control of binding interactions. There is a clear need for small molecule platforms that can be controlled...
|
|
Background
Electron sources used in free-electron lasers, advanced microscopy, and next-generation particle accelerators suffer a trade-off between brightness, efficiency, operational lifetimes, and average current. The current systems give strong emission and improved electron multiplication, but they do not meet operational standards. A more robust...
|
|
Background
Androgen receptor activity, mediated by androgens like dihydrotestosterone (DHT), is a key driver of prostate cancer (PCa). Although hormonal therapy remains the cornerstone of PCatreatment, patient responses are highly variable, and it remains difficult to reliably predict who will benefit. Developing predictive biomarkers and accessible...
|
|
Background
Functional ultrasound imaging is a promising neuroimaging technology with potential to unlock next-generation brain-computer interfaces (BCI). However, ultrasound imaging through the skull is limited by the impedance mismatch between bone and brain tissue, causing reflection, scattering, and signal loss, resulting in poor transmission and...
|
|
Background
Carbon fiber prepregs are widely used in aerospace and high-performance manufacturing since they can produce lightweight, high-strength composite structures. However, prepregs have a limited storage life, and an estimated 30–50% of prepreg material used is ultimately discarded due to expiration or manufacturing scrap. A recycling solution...
|
|
Novel lipid-amino acid prodrug platform enhances delivery of nucleoside phosphonate antivirals for SARS-CoV-2 treatment.
Conjugates amino acid promoieties to antiviral compounds to improve solubility, permeability, metabolic activation, and tissue targeting.
Evaluated using an immunosuppressed Syrian hamster model that closely reflects severe...
|