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Background
Many advanced materials and molecular systems require precise, reversible control over molecular interactions. Applications for responsive materials, biomedical systems and adaptive surfaces need on-demand, localized, and reversible control of binding interactions. There is a clear need for small molecule platforms that can be controlled...
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Background
Electron sources used in free-electron lasers, advanced microscopy, and next-generation particle accelerators suffer a trade-off between brightness, efficiency, operational lifetimes, and average current. The current systems give strong emission and improved electron multiplication, but they do not meet operational standards. A more robust...
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Background
Androgen receptor activity, mediated by androgens like dihydrotestosterone (DHT), is a key driver of prostate cancer (PCa). Although hormonal therapy remains the cornerstone of PCatreatment, patient responses are highly variable, and it remains difficult to reliably predict who will benefit. Developing predictive biomarkers and accessible...
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Background
Functional ultrasound imaging is a promising neuroimaging technology with potential to unlock next-generation brain-computer interfaces (BCI). However, ultrasound imaging through the skull is limited by the impedance mismatch between bone and brain tissue, causing reflection, scattering, and signal loss, resulting in poor transmission and...
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Background
Carbon fiber prepregs are widely used in aerospace and high-performance manufacturing since they can produce lightweight, high-strength composite structures. However, prepregs have a limited storage life, and an estimated 30–50% of prepreg material used is ultimately discarded due to expiration or manufacturing scrap. A recycling solution...
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Novel lipid-amino acid prodrug platform enhances delivery of nucleoside phosphonate antivirals for SARS-CoV-2 treatment.
Conjugates amino acid promoieties to antiviral compounds to improve solubility, permeability, metabolic activation, and tissue targeting.
Evaluated using an immunosuppressed Syrian hamster model that closely reflects severe...
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Uses steady-state visually evoked potentials (SSVEPs) as endogenous reference signals for cross-session EEG calibration.
Creates a subject-specific linear mapping that aligns raw EEG recordings to a common neural baseline.
Reduces the impact of session dependent recording differences to support consistent longitudinal EEG analysis.
Abstract
This...
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Highlight
Reprograms cancer-associated fibroblasts to dismantle tumor barriers and improve immune-cell access to solid tumors.
Innovation
Cancer-associated fibroblasts (CAFs) create a physical and immunosuppressive barrier that limits the effectiveness of CAR-T and other immunotherapies in solid tumors. This technology uses transcription factor-based...
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End-to-end spatial proteomics pipeline integrating image correction, cell segmentation, and cell phenotyping
Identifies both common and rare cell populations through semi-supervised clustering for deeper tissue characterization
Generates clinically actionable insights that can predict outcomes such as organ transplant rejection
Abstract
The inventors...
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Novel ASO therapeutic targeting CCDC146, a newly identified driver of motor neuron degeneration in ALS
Demonstrated efficacy across both sporadic and familial ALS models, supporting broad patient applicability
Improves motor function, neuronal survival, and lifespan in preclinical ALS models
Abstract
USC researchers have developed a targeted antisense...
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