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2026-018 - Smart Ring for Continuous, AI-Enabled Stress Monitoring

BRIEF DESCRIPTION A contactless smart ring that optically tracks stress-related physiology and uses on-device AI for continuous stress monitoring. BACKGROUND Continuous stress monitoring could support personal wellness, workplace safety, and clinical care, but conventional electrodermal activity (EDA) sensors depend on skin-contact electrodes and...

2024-136 - AI-Powered Ingestible Capsule Tracking for Remote Monitoring of Gastrointestinal Disorders

Background Gastrointestinal disorders are closely tied to spatially varying gas concentrations (e.g., O₂, NH₃, H₂, CH₄) in the gut. However, existing diagnostic methods, lack the ability to noninvasively and/or continuously monitor region-specific gas levels. Ingestible capsules are a promising solution but still require imaging equipment that come...

SCHMOOSE: Novel therapeutic peptides for neurodegeneration

Novel microprotein therapeutic that restores mitochondrial function to address neurodegeneration Reduces neuroinflammation and improves brain metabolism for broad neuroprotective effects Demonstrated efficacy in in vitro and in vivo models of neurodegenerative disease Abstract USC researchers have identified SHMOOSE, a novel mitochondrial microprotein...

Published: 7/22/2026 Inventor(s): Pinchas Cohen, Su Jeong Kim, Brendan Miller
Category(s): Life Sciences

Novel (2-oxo-2H-chromen-3-yl) scaffold based carboxamide analogs as potent inhibitors of tau protein fibrils

Small-molecule carboxamides that inhibit and disassemble tau fibrils associated with Alzheimer’s disease Optimized for blood-brain barrier penetration and favorable pharmacokinetic properties Demonstrated efficacy in Alzheimer’s disease brain tissue and cell-based models Abstract USC researchers have developed carboxamide-based small...

Published: 7/22/2026 Inventor(s): Paul Seidler, Syed Ahmed, Nader Mostowfi
Category(s): Life Sciences

2026-020 - INT-DTT+: Adaptive Low-Complexity Video Compression

Background Modern compression systems use a set of fixed mathematical tools to remove unnecessary information from each video frame. While these tools work well, they treat most video content in the same way and cannot adapt to the unique characteristics of each scene. As video resolutions, frame rates, and streaming demands continue to increase,...

2024-164 Multimodal Nondestructive Evaluation Platform

Background Thousands of tons of spent nuclear fuel around the world have been locked away in stainless-steel canisters with limited lifetimes and an imminent need of transportation or potential repackaging. Current inspection tools are Invasive and costly Lengthy Unable to detect critical damage modes Technology Description USC researchers...

Published: 7/13/2026 Inventor(s): Bora Gencturk, Anna Arcaro, Bozhou Zhuang

2026-098: Light-Triggered Zwitterionic Photoswitches for Dynamic Molecular Interactions

Background Many advanced materials and molecular systems require precise, reversible control over molecular interactions. Applications for responsive materials, biomedical systems and adaptive surfaces need on-demand, localized, and reversible control of binding interactions. There is a clear need for small molecule platforms that can be controlled...

2026-125 - Air-Stable Diamond Electron Amplifier for Next-Generation Beam Sources

Background Electron sources used in free-electron lasers, advanced microscopy, and next-generation particle accelerators suffer a trade-off between brightness, efficiency, operational lifetimes, and average current. The current systems give strong emission and improved electron multiplication, but they do not meet operational standards. A more robust...

2025-001 - Inherited variants in SRD5A genes and response to hormonal therapy in prostate cancer

Background Androgen receptor activity, mediated by androgens like dihydrotestosterone (DHT), is a key driver of prostate cancer (PCa). Although hormonal therapy remains the cornerstone of PCatreatment, patient responses are highly variable, and it remains difficult to reliably predict who will benefit. Developing predictive biomarkers and accessible...

2025-185 - Skull acoustic transparency

Background Functional ultrasound imaging is a promising neuroimaging technology with potential to unlock next-generation brain-computer interfaces (BCI). However, ultrasound imaging through the skull is limited by the impedance mismatch between bone and brain tissue, causing reflection, scattering, and signal loss, resulting in poor transmission and...

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