|
BRIEF DESCRIPTION
A contactless smart ring that optically tracks stress-related physiology and uses on-device AI for continuous stress monitoring.
BACKGROUND
Continuous stress monitoring could support personal wellness, workplace safety, and clinical care, but conventional electrodermal activity (EDA) sensors depend on skin-contact electrodes and...
|
|
Background
Gastrointestinal disorders are closely tied to spatially varying gas concentrations (e.g., O₂, NH₃, H₂, CH₄) in the gut. However, existing diagnostic methods, lack the ability to noninvasively and/or continuously monitor region-specific gas levels. Ingestible capsules are a promising solution but still require imaging equipment that come...
|
|
Novel microprotein therapeutic that restores mitochondrial function to address neurodegeneration
Reduces neuroinflammation and improves brain metabolism for broad neuroprotective effects
Demonstrated efficacy in in vitro and in vivo models of neurodegenerative disease
Abstract
USC researchers have identified SHMOOSE, a novel mitochondrial microprotein...
|
|
Small-molecule carboxamides that inhibit and disassemble tau fibrils associated with Alzheimer’s disease
Optimized for blood-brain barrier penetration and favorable pharmacokinetic properties
Demonstrated efficacy in Alzheimer’s disease brain tissue and cell-based models
Abstract
USC researchers have developed carboxamide-based small...
|
|
Background
Androgen receptor activity, mediated by androgens like dihydrotestosterone (DHT), is a key driver of prostate cancer (PCa). Although hormonal therapy remains the cornerstone of PCatreatment, patient responses are highly variable, and it remains difficult to reliably predict who will benefit. Developing predictive biomarkers and accessible...
|
|
Background
Functional ultrasound imaging is a promising neuroimaging technology with potential to unlock next-generation brain-computer interfaces (BCI). However, ultrasound imaging through the skull is limited by the impedance mismatch between bone and brain tissue, causing reflection, scattering, and signal loss, resulting in poor transmission and...
|
|
Novel lipid-amino acid prodrug platform enhances delivery of nucleoside phosphonate antivirals for SARS-CoV-2 treatment.
Conjugates amino acid promoieties to antiviral compounds to improve solubility, permeability, metabolic activation, and tissue targeting.
Evaluated using an immunosuppressed Syrian hamster model that closely reflects severe...
|
|
Uses steady-state visually evoked potentials (SSVEPs) as endogenous reference signals for cross-session EEG calibration.
Creates a subject-specific linear mapping that aligns raw EEG recordings to a common neural baseline.
Reduces the impact of session dependent recording differences to support consistent longitudinal EEG analysis.
Abstract
This...
|
|
Highlight
Reprograms cancer-associated fibroblasts to dismantle tumor barriers and improve immune-cell access to solid tumors.
Innovation
Cancer-associated fibroblasts (CAFs) create a physical and immunosuppressive barrier that limits the effectiveness of CAR-T and other immunotherapies in solid tumors. This technology uses transcription factor-based...
|
|
End-to-end spatial proteomics pipeline integrating image correction, cell segmentation, and cell phenotyping
Identifies both common and rare cell populations through semi-supervised clustering for deeper tissue characterization
Generates clinically actionable insights that can predict outcomes such as organ transplant rejection
Abstract
The inventors...
|