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Background
Many advanced materials and molecular systems require precise, reversible control over molecular interactions. Applications for responsive materials, biomedical systems and adaptive surfaces need on-demand, localized, and reversible control of binding interactions. There is a clear need for small molecule platforms that can be controlled...
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Background
Androgen receptor activity, mediated by androgens like dihydrotestosterone (DHT), is a key driver of prostate cancer (PCa). Although hormonal therapy remains the cornerstone of PCatreatment, patient responses are highly variable, and it remains difficult to reliably predict who will benefit. Developing predictive biomarkers and accessible...
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Background
Functional ultrasound imaging is a promising neuroimaging technology with potential to unlock next-generation brain-computer interfaces (BCI). However, ultrasound imaging through the skull is limited by the impedance mismatch between bone and brain tissue, causing reflection, scattering, and signal loss, resulting in poor transmission and...
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Novel lipid-amino acid prodrug platform enhances delivery of nucleoside phosphonate antivirals for SARS-CoV-2 treatment.
Conjugates amino acid promoieties to antiviral compounds to improve solubility, permeability, metabolic activation, and tissue targeting.
Evaluated using an immunosuppressed Syrian hamster model that closely reflects severe...
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Uses steady-state visually evoked potentials (SSVEPs) as endogenous reference signals for cross-session EEG calibration.
Creates a subject-specific linear mapping that aligns raw EEG recordings to a common neural baseline.
Reduces the impact of session dependent recording differences to support consistent longitudinal EEG analysis.
Abstract
This...
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Highlight
Reprograms cancer-associated fibroblasts to dismantle tumor barriers and improve immune-cell access to solid tumors.
Innovation
Cancer-associated fibroblasts (CAFs) create a physical and immunosuppressive barrier that limits the effectiveness of CAR-T and other immunotherapies in solid tumors. This technology uses transcription factor-based...
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End-to-end spatial proteomics pipeline integrating image correction, cell segmentation, and cell phenotyping
Identifies both common and rare cell populations through semi-supervised clustering for deeper tissue characterization
Generates clinically actionable insights that can predict outcomes such as organ transplant rejection
Abstract
The inventors...
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Novel ASO therapeutic targeting CCDC146, a newly identified driver of motor neuron degeneration in ALS
Demonstrated efficacy across both sporadic and familial ALS models, supporting broad patient applicability
Improves motor function, neuronal survival, and lifespan in preclinical ALS models
Abstract
USC researchers have developed a targeted antisense...
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First scalable human cerebellar organoid platform capable of generating mature, functional Purkinje cells
Recapitulates human cerebellar architecture and cellular diversity for more predictive disease modeling
Enables high-throughput drug screening and therapeutic discovery for neurodevelopmental and neurodegenerative disorders
Abstract
USC researchers...
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Novel small-molecule Piezo1 agonists with high selectivity, strong metabolic stability, and minimal CYP450 interactions
Enhances cerebrospinal fluid and lymphatic drainage through activation of Akt and eNOS signaling pathways
Demonstrated reduction of ventricular fluid accumulation in hydrocephalus animal models, supporting therapeutic potential for...
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