|
Background
Functional ultrasound imaging is a promising neuroimaging technology with potential to unlock next-generation brain-computer interfaces (BCI). However, ultrasound imaging through the skull is limited by the impedance mismatch between bone and brain tissue, causing reflection, scattering, and signal loss, resulting in poor transmission and...
|
|
Prognostic biomarkers for brain tumors and immunotherapies for glioblastoma multiforme
RNA based biotherapeutics
Abstract
USC researchers have discovered long non-coding RNAs (lncRNAs) that were aberrantly expressed specifically in GBM brains relative to normal brains. These lncRNAs had prognostic significance and could serve as prognostic...
|
|
Bioinformatics
Personal genomics
Abstract
USC researchers have designed the first tool that bridges genomic data mining and prior cancer search knowledge. This statistical model leverages personal genomic information with a large biological database to facilitate cancer diagnostics and personalize cancer treatment.
Benefit
User-friendly tool
Facilitate...
|
|
Bioinformatics
Personal genomics
Abstract
USC researchers have developed an integrative tool named Phenolyzer, a phenotype-based gene analyzer. Phenolyzer takes a discrete list of phenotype terms as input and generates a list of candidate genes weighted by the chance of being associated with the phenotype, even in the absence of any genotype data....
|
|
Novel protein-based targeted drug delivery strategy
Potential application to treat several ocular disorders
Uses biocompatible, biodegradable and less immunogenic ELP-1 polymers
Abstract
USC scientists genetically engineered elastin-like polypeptides (ELP), which assemble multivalent nanoparticles at physiological temperature. The innovation was...
|