Search Results - john+mackay

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2017-147 - Elastin-like Polypeptide Fusion Proteins Establish Novel Drug Carrier Strategy

Treatment for organ rejection and autoimmune diseases Drug carrier Abstract USC researchers have developed a novel strategy to carry CsA by binding it to its cognate receptor, cyclophilin. Significantly improved pharmacokinetic (PK) profile and therefore reduced systemic side effect were achieved by fusing cyclophilin with different types of elastin-like...

Published: 12/13/2025 Inventor(s): John MacKay, Sarah Hamm-Alvarez, Mihir Shah, Hao Guo
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11-692 - Polypeptide Nanoparticles for Controlled Release of Ocular Biopharmaceuticals

Novel protein-based targeted drug delivery strategy Potential application to treat several ocular disorders Uses biocompatible, biodegradable and less immunogenic ELP-1 polymers Abstract USC scientists genetically engineered elastin-like polypeptides (ELP), which assemble multivalent nanoparticles at physiological temperature. The innovation was...

Published: 12/12/2025 Inventor(s): John MacKay, Wan Wang
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