Search Results - young-kwon+hong

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2023-021 - Novel chemical compounds regulating Piezo1 activity

Novel small-molecule Piezo1 agonists with high selectivity, strong metabolic stability, and minimal CYP450 interactions Enhances cerebrospinal fluid and lymphatic drainage through activation of Akt and eNOS signaling pathways Demonstrated reduction of ventricular fluid accumulation in hydrocephalus animal models, supporting therapeutic potential for...

Published: 6/2/2026 Inventor(s): Young-Kwon Hong, Hongchan Ahn, Jungwook Chin, Sung Jin Cho, Ye Rin Choi, Minseon Jeong, Min Young Kim, Soyeong Kim, Su-Jeong Lee, Sung Hwan Kim, Ha-Yeon Lee, Yeong Hye Park, Ji Hoon Yu, Syed Ahmed

Category(s): Life Sciences, Life Sciences > Therapeutics & Drug Development

2019-087 - Prevention and Treatment of Post-Surgical Lymphedema

For the treatment of post-surgical lymphedema To encourage lymphangiogenesis in tissue Abstract Researchers at USC have recently demonstrated that the compound 9-cis retinoic acid (RA) stimulates the proliferation of lymphatic vessels without promoting tumor metastasis in mice. The drug is administered during surgery, releasing 9-cis RA into the...

Published: 3/11/2026 Inventor(s): Alex Wong, Young-Kwon Hong, Giulia Daneshgaran

Category(s): Life Sciences > Therapeutics & Drug Development, Life Sciences > Medical Devices & Delivery Platforms, Life Sciences

2019-008 - Piezo1 and Its Agonist Yoda1 in Lymphatic Vessels and Valves

For the treatment of: Lymphatic valve disorders Ocular hypertension Brain injury Lymphedema Abstract USC researchers have recently elucidated the function of Piezo1 in embryonic and postnatal lymphatic growth and valve development, proposing that it functions as a mechanotransduction sensor that senses cell stretch caused by oscillatory...

Published: 3/11/2026 Inventor(s): Young-Kwon Hong, Dong Choi

Category(s): Life Sciences > Therapeutics & Drug Development, Life Sciences