Search Results - syed+ahmed

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Novel (2-oxo-2H-chromen-3-yl) scaffold based carboxamide analogs as potent inhibitors of tau protein fibrils

Small-molecule carboxamides that inhibit and disassemble tau fibrils associated with Alzheimer’s disease Optimized for blood-brain barrier penetration and favorable pharmacokinetic properties Demonstrated efficacy in Alzheimer’s disease brain tissue and cell-based models Abstract USC researchers have developed carboxamide-based small...

Published: 7/22/2026 Inventor(s): Paul Seidler, Syed Ahmed, Nader Mostowfi

Category(s): Life Sciences

2023-021 - Novel chemical compounds regulating Piezo1 activity

Novel small-molecule Piezo1 agonists with high selectivity, strong metabolic stability, and minimal CYP450 interactions Enhances cerebrospinal fluid and lymphatic drainage through activation of Akt and eNOS signaling pathways Demonstrated reduction of ventricular fluid accumulation in hydrocephalus animal models, supporting therapeutic potential for...

Published: 6/2/2026 Inventor(s): Young-Kwon Hong, Hongchan Ahn, Jungwook Chin, Sung Jin Cho, Ye Rin Choi, Minseon Jeong, Min Young Kim, Soyeong Kim, Su-Jeong Lee, Sung Hwan Kim, Ha-Yeon Lee, Yeong Hye Park, Ji Hoon Yu, Syed Ahmed

Category(s): Life Sciences, Life Sciences > Therapeutics & Drug Development

2024-143 - Novel N-(chroman-3-yl) benzamide analogs as potent antimicrobial agents, and immune activators

Abstract USC scientists have developed novel N-(chroman-3-yl) benzamide compounds, which have shown potent antimicrobial activity against antibiotic-resistant Staphylococcus aureus (SA) and enhanced immune cell killing. In vitro tests revealed a four-fold reduction in the concentration needed to inhibit the growth of the bacterium. When these compounds...

Published: 3/11/2026 Inventor(s): Annie Wong-Beringer, Syed Ahmed, Paul Beringer, Vy Nguyen, Riley Grosso

Category(s): Life Sciences > Therapeutics & Drug Development, Life Sciences