Search Results - syed+ahmed

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2023-021 - Novel chemical compounds regulating Piezo1 activity

Novel small-molecule Piezo1 agonists with high selectivity, strong metabolic stability, and minimal CYP450 interactions Enhances cerebrospinal fluid and lymphatic drainage through activation of Akt and eNOS signaling pathways Demonstrated reduction of ventricular fluid accumulation in hydrocephalus animal models, supporting therapeutic potential for...

2024-143 - Novel N-(chroman-3-yl) benzamide analogs as potent antimicrobial agents, and immune activators

Abstract USC scientists have developed novel N-(chroman-3-yl) benzamide compounds, which have shown potent antimicrobial activity against antibiotic-resistant Staphylococcus aureus (SA) and enhanced immune cell killing. In vitro tests revealed a four-fold reduction in the concentration needed to inhibit the growth of the bacterium. When these compounds...