Search Results - paul+beringer

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2020-143 - Engineered Cyclotides with Potent Broad Antimicrobial Activity

Antibacterial therapeutic Abstract USC researchers engineered novel cyclotide with effective broad-spectrum antibacterial activity against several ESKAPE bacterial strains and clinical isolates. Cyclotides are micro-proteins (˜30 residues long) that have shown remarkable stability, are easily synthesized and have shown good oral bioavailability....

2024-143 - Novel N-(chroman-3-yl) benzamide analogs as potent antimicrobial agents, and immune activators

2024-143 Background Staphylococcus aureus is a leading cause of serious bloodstream and hospital-acquired infections, and methicillin-resistant S. aureus (MRSA) limits the effectiveness of standard antibiotics. S. aureus can also survive within macrophages, creating an intracellular reservoir that is difficult for conventional antibiotics and host...