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Background
Heart failure with preserved ejection fraction (HFpEF) due to left ventricular (LV) diastolic dysfunction is a growing clinical challenge. Currently, the gold standard diagnostic method is invasive procedures like cardiac catheterization with direct measurement of LV pressure decay. These invasive methods are costly, time-consuming, and...
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Background
Target engagement quantification is crucial in drug discovery for understanding drug-protein interactions, mechanisms of action, and resistance. Traditional methods like activity-based protein profiling with gel fluorescence, while effective, are limited by low throughput, long processing times, and disruption of native protein functions....
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Background
G-protein-coupled receptors (GPCRs) are pivotal in cell signaling and represent a major target class for drug development. Among them, cannabinoid receptors, especially CB2, play a crucial role in regulating neuroinflammation and immune responses. Current therapeutic options inadequately modulate CB2 activity, limiting effective treatment...
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Miniaturized Transcranial Magnetic Stimulation (TMS) Coil
C-shaped Magnetic Coil Neuromodulation in Small Animals
Electrophysiological Recording and Stimulation
Behaviorally Validated: Demonstrated the ability to produce measurable, phase-specific changes in spatial learning, memory retention, and cognitive flexibility in freely behaving rats.
Abstract
Transcranial...
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Kidney organoids
Proximal tubule
Nephrotoxicity modeling
Abstract
Kidney organoids have emerged as powerful models to replicate human kidney function, especially focusing on the proximal tubule, a key segment responsible for reabsorption and secretion. Current organoid systems, however, struggle to accurately mimic the complex physiology and injury...
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Quantum Adaptive Sensing
k-space sampling
Quantum annealing
Magnetic Resonance Imaging
Abstract
Magnetic Resonance Imaging (MRI) technology relies on sampling k-space, a spatial-frequency domain, to reconstruct high-quality images. Traditional methods fully sample k-space, which leads to long scan times and patient discomfort. Compressed sensing...
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Novel microprotein therapeutic that restores mitochondrial function to address neurodegeneration
Reduces neuroinflammation and improves brain metabolism for broad neuroprotective effects
Demonstrated efficacy in in vitro and in vivo models of neurodegenerative disease
Abstract
USC researchers have identified SHMOOSE, a novel mitochondrial microprotein...
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Small-molecule carboxamides that inhibit and disassemble tau fibrils associated with Alzheimer’s disease
Optimized for blood-brain barrier penetration and favorable pharmacokinetic properties
Demonstrated efficacy in Alzheimer’s disease brain tissue and cell-based models
Abstract
USC researchers have developed carboxamide-based small...
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Background
Androgen receptor activity, mediated by androgens like dihydrotestosterone (DHT), is a key driver of prostate cancer (PCa). Although hormonal therapy remains the cornerstone of PCatreatment, patient responses are highly variable, and it remains difficult to reliably predict who will benefit. Developing predictive biomarkers and accessible...
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Novel lipid-amino acid prodrug platform enhances delivery of nucleoside phosphonate antivirals for SARS-CoV-2 treatment.
Conjugates amino acid promoieties to antiviral compounds to improve solubility, permeability, metabolic activation, and tissue targeting.
Evaluated using an immunosuppressed Syrian hamster model that closely reflects severe...
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