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Background
Heart failure with preserved ejection fraction (HFpEF) due to left ventricular (LV) diastolic dysfunction is a growing clinical challenge. Currently, the gold standard diagnostic method is invasive procedures like cardiac catheterization with direct measurement of LV pressure decay. These invasive methods are costly, time-consuming, and...
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Miniaturized Transcranial Magnetic Stimulation (TMS) Coil
C-shaped Magnetic Coil Neuromodulation in Small Animals
Electrophysiological Recording and Stimulation
Behaviorally Validated: Demonstrated the ability to produce measurable, phase-specific changes in spatial learning, memory retention, and cognitive flexibility in freely behaving rats.
Abstract
Transcranial...
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Functional ultrasound imaging
Interictal epilepsy assessment
Epileptogenic tissue localization
Responsive neurostimulation
Abstract
Epilepsy remains a challenging neurological disorder, particularly in localizing epileptogenic tissue critical for effective treatment. Traditional approaches depend heavily on capturing active seizures (ictal events)...
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Quantum Adaptive Sensing
k-space sampling
Quantum annealing
Magnetic Resonance Imaging
Abstract
Magnetic Resonance Imaging (MRI) technology relies on sampling k-space, a spatial-frequency domain, to reconstruct high-quality images. Traditional methods fully sample k-space, which leads to long scan times and patient discomfort. Compressed sensing...
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BRIEF DESCRIPTION
A contactless smart ring that optically tracks stress-related physiology and uses on-device AI for continuous stress monitoring.
BACKGROUND
Continuous stress monitoring could support personal wellness, workplace safety, and clinical care, but conventional electrodermal activity (EDA) sensors depend on skin-contact electrodes and...
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Background
Gastrointestinal disorders are closely tied to spatially varying gas concentrations (e.g., O₂, NH₃, H₂, CH₄) in the gut. However, existing diagnostic methods, lack the ability to noninvasively and/or continuously monitor region-specific gas levels. Ingestible capsules are a promising solution but still require imaging equipment that come...
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Background
Androgen receptor activity, mediated by androgens like dihydrotestosterone (DHT), is a key driver of prostate cancer (PCa). Although hormonal therapy remains the cornerstone of PCatreatment, patient responses are highly variable, and it remains difficult to reliably predict who will benefit. Developing predictive biomarkers and accessible...
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End-to-end spatial proteomics pipeline integrating image correction, cell segmentation, and cell phenotyping
Identifies both common and rare cell populations through semi-supervised clustering for deeper tissue characterization
Generates clinically actionable insights that can predict outcomes such as organ transplant rejection
Abstract
The inventors...
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COVID-19 detection
Viral detection
Cancer marker detection
Abstract
USC inventors propose a novel selectively-sensing bio-photonics microfluidic optical ring resonator-based integrated chip architecture with an on-chip spectrometer consisting of coupled ring resonator filters and integrated photodetector arrays for detection of COVID-19. The design...
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Cancer diagnostic
Pathology
Biomarker imaging
Abstract
USC researchers have developed a novel multiplexed surface enhanced Raman scattering nanoparticle (SERS NP) strategy that exploits the power of Raman spectroscopy for molecular mapping of tumors from patient samples. Multiplexed SERS NPs will be conjugated with tumor-biomarker targeting ligands...
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