Description:
- Diagnosis of human tumors
Abstract
A USC researcher has generated a hybridoma clone, LN-6, that recognizes the human protein, vimentin, in formalin fixed paraffin embedded tissues that can recognize different cell constituents of lymph nodes and bone marrow. This biomarker is useful for immunodiagnosis of human sarcomas and tumors of mesenchymal origin and is also useful in the identification of new tumor cell lines and cell strains.
Benefit
- Retains its immunoreactivity in B5-fixed, paraffin-embedded tissue sections, which enables one to use this reagent in routinely process specimens
- Unreactive with both normal and malignant lymphoid and hematopoietic cells
Market Application
The existence of monoclonal antibodies (MAb) have made it possible to diagnosis a variety of cancers. However, because soft tissue neoplasms are uncommon and have a wide variation in histological appearance, their identification can be difficult and the histopathologist must often rely on immunological methods to provide additional data to support the diagnosis. Moreover, MAb to many antigens are not reactive in fixed, paraffin-embedded tissues, and none can distinguish between lymphoid tumors and non-hematopoietic soft tissue neoplasms.
Publications
LN-6: a monoclonal antibody to vimentin expressed in non-hematopoietic mesenchymal cells and derived tumors and reactive in B5-fixed, paraffin-embedded tissues. J Histochem Cytochem. (1989).