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Research tools for identifying various cellular properties
Abstract
USC researchers have generated monoclonal antibodies that recognize and bind to a single epitope on specific antigens for a variety of cells and subcellular properties. Their specificity will ensure more accurate results than their polyclonal counterparts.
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Research and diagnostic
Flow cytometry
Histopathology
Abstract
A USC researcher has generated a murine monoclonal antibody, 58-15. Since the antibody can be used in paraffin embedded tissue sections, it can identify actively cycling cells within a tissue specimen, making it a useful tool for immunopathologic studies on tissues from which prognostic...
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Reduction of tumor growth using immune checkpoint inhibitors
Abstract
Researchers at USC have generated antibodies which enhance adaptive anti-tumor immune response by eliciting innate immunity. The antibodies are conjugated to CpG, a Toll-like receptor 9 agonist, which activates innate immune cells. Preclinical studies showed that CpG-conjugated...
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Diagnosis of human tumors
Abstract
A USC researcher has generated a hybridoma clone, LN-6, that recognizes the human protein, vimentin, in formalin fixed paraffin embedded tissues that can recognize different cell constituents of lymph nodes and bone marrow. This biomarker is useful for immunodiagnosis of human sarcomas and tumors of mesenchymal...
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Seminoma (testicular cancer)
Abstract
A USC researcher has generated the first cell line, SEM-1, derived from an extragonadal germ cell tumor showing intermediate characteristics between seminoma and nonseminoma, making it an important model to study the molecular pathogenesis of this malignancy. Additionally, because SEM-1 was derived from a tumor...
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Research tool for developing therapeutics for primary breast Non-Hodgkin's Lymphoma
Abstract
USC scientists have derived four human T-cell lymphoma breast-1 (TLBR) cell lines from women who developed breast lymphomas after breast implantation and designated them TLBR-1, -2, -3, and -4. They characterized all four cell lines with respect to their...
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Hybridoma and monoclonal antibodies for human macrophage markers
Abstract
A USC researcher has generated monoclonal antibodies, LN-4 and LN-5, reactive to human macrophages in B5 formalin-fixed, paraffin-embedded tissue sections. LN-4 has specificity for phagocytic macrophages and epithelioid histiocytes in hematopoietic tissues, while LN-5 demonstrated...
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