Description:
- Seminoma (testicular cancer)
Abstract
A USC researcher has generated the first cell line, SEM-1, derived from an extragonadal germ cell tumor showing intermediate characteristics between seminoma and nonseminoma, making it an important model to study the molecular pathogenesis of this malignancy. Additionally, because SEM-1 was derived from a tumor that later recurred, it can be an excellent model in studying more aggressive, chemo-resistant seminomas.
Benefit
- First extragonadal seminoma tumor model
- Can be useful in studying more aggressive, treatment-resistant seminomas
Market Application
Germ cell tumors (GCT) are the most frequently diagnosed malignancy in men. Type II GCT, which are classified as seiminomatous or nonseminomatous, most commonly arise in the testis. With the exception of primary tumor samples, few tools are available to study the molecular pathogenesis of seminoma. To date, there are only 2 cell lines that exist. However, one has been shown to be dissimilar from its original tumor in that it does not express pure classical seminoma markers and neither models extragonadal treatment-resistant seminomas.
Publications
Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1. Urology. (2013).
Other
- Cell line generated and characterized