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Background
Androgen receptor activity, mediated by androgens like dihydrotestosterone (DHT), is a key driver of prostate cancer (PCa). Although hormonal therapy remains the cornerstone of PCatreatment, patient responses are highly variable, and it remains difficult to reliably predict who will benefit. Developing predictive biomarkers and accessible...
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End-to-end spatial proteomics pipeline integrating image correction, cell segmentation, and cell phenotyping
Identifies both common and rare cell populations through semi-supervised clustering for deeper tissue characterization
Generates clinically actionable insights that can predict outcomes such as organ transplant rejection
Abstract
The inventors...
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COVID-19 detection
Viral detection
Cancer marker detection
Abstract
USC inventors propose a novel selectively-sensing bio-photonics microfluidic optical ring resonator-based integrated chip architecture with an on-chip spectrometer consisting of coupled ring resonator filters and integrated photodetector arrays for detection of COVID-19. The design...
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Cancer diagnostic
Pathology
Biomarker imaging
Abstract
USC researchers have developed a novel multiplexed surface enhanced Raman scattering nanoparticle (SERS NP) strategy that exploits the power of Raman spectroscopy for molecular mapping of tumors from patient samples. Multiplexed SERS NPs will be conjugated with tumor-biomarker targeting ligands...
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Cancer research
Cancer treatment
Abstract
USC researchers have developed a technique to determine the molecular subtype of a breast cancer tumor in archival samples. This in vitro, RNA-based, multi-parameter molecular diagnostic method has been extensively tested on challenging aged and degraded tissue samples to optimize the choice of probes. The...
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Radiolabeled diagnostic tracer for PET imaging/scans
Cancer and cardiovascular imaging
Abstract
Radiolabeled diagnostic tracer for PET imaging/scans
Cancer and cardiovascular imaging
Benefit
Useful for in vivo imaging of tumor and organ tissues (e.g., heart, liver, brain, kidneys
Direct ?uorination method of synthesis is convenient, produces...
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Magnetic resonance imaging
Tracer kinetic map generation
Disease diagnosis and monitoring
Abstract
USC researchers have developed a method of DCE-MRI reconstruction that allows different TK models and solvers to be integrated, as well as joint estimation of patient-specific AIF and TK maps. This is achieved by setting the TK model consistency as...
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Diagnosis of human tumors
Abstract
A USC researcher has generated a hybridoma clone, LN-6, that recognizes the human protein, vimentin, in formalin fixed paraffin embedded tissues that can recognize different cell constituents of lymph nodes and bone marrow. This biomarker is useful for immunodiagnosis of human sarcomas and tumors of mesenchymal...
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CTC collection is minimally invasive and considered a "liquid biopsy" of solid tumors
Can be used to identify mechanisms underlying metastasis-initiating properties in any metastatic cancer
Compounds identified that increase proliferation of patient CTCs ex vivo will allow for large-scale screening of cancer treatments and possibly personalized...
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Medical imaging
MRI scanners
Oncology
Abstract
USC researchers have developed a direct reconstruction method – a method that directly reconstructs the tracker-kinetic (TK) parameter maps. This method provides improved image quality and high under-sampling rates (up to 100x) over a large coverage area (e.g. the entire brain). These improvements...
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