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Background
A key barrier to CAR-T cell therapies for solid tumors is the immunosuppressive tumor microenvironment, where cytokines like TGF-β inhibit T cell proliferation, cytotoxicity, and persistence. TGF-β suppresses immune responses by activating Smad-dependent signaling pathways, leading to T cell anergy and exhaustion. Traditional approaches...
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Background
Cancer stem-like cells (CSLCs) are a primary driver of tumor relapse, metastasis, and resistance to immunotherapy, particularly in solid tumors. Mechanical softness within the tumor microenvironment promotes immune evasion, yet current CAR-T strategies lack effective approaches to identify and eliminate these mechanically resistant cell...
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Treatment and prevention of tumor formation and metastasis
Research reagent (monoclonal antibody)
Abstract
USC scientists recently developed a monoclonal antibody, called 1G6-D7, which targets tumor-secreted Hsp90a. 1G6-D7 binds the active site of tumor-secreted Hsp90a and inhibits both de novo tumor formation and expansion of pre-formed tumors...
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LoS communication systems
Cell phone communication systems
Emergency communication systems
Abstract
USC researchers have developed a high-speed mm-wave communication link achieving a data rate of 16 Gbit/s. The link utilizes Multiple-Input Multiple-Output (MIMO) processing of two Orbital Angular Momentum (OAM) modes on each of the transmitter and...
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