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Background
Advancements in gene editing have revolutionized biomedical research and therapeutic development, yet current methods lack precise, non-invasive control over gene expression in living organisms. Conventional gene modulation approaches, including chemical inducers and viral vectors, often result in systemic effects, off-target activity, and...
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Background
Natural cellular signaling networks decode dynamic input features such as frequency to produce precise, context-dependent responses, whereas most existing synthetic and optogenetic systems are limited to binary on/off control. This inability to interpret dynamic input states fundamentally constrains the precise and tunable regulation of...
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Background
A key barrier to CAR-T cell therapies for solid tumors is the immunosuppressive tumor microenvironment, where cytokines like TGF-β inhibit T cell proliferation, cytotoxicity, and persistence. TGF-β suppresses immune responses by activating Smad-dependent signaling pathways, leading to T cell anergy and exhaustion. Traditional approaches...
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Background
Cancer stem-like cells (CSLCs) are a primary driver of tumor relapse, metastasis, and resistance to immunotherapy, particularly in solid tumors. Mechanical softness within the tumor microenvironment promotes immune evasion, yet current CAR-T strategies lack effective approaches to identify and eliminate these mechanically resistant cell...
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Novel protein-based targeted drug delivery strategy
Potential application to treat several ocular disorders
Uses biocompatible, biodegradable and less immunogenic ELP-1 polymers
Abstract
USC scientists genetically engineered elastin-like polypeptides (ELP), which assemble multivalent nanoparticles at physiological temperature. The innovation was...
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