Description:
- Chondral, osteochondral, and rotator tendon defect treatment
- Rotator cuff tear treatment
- Tendon and cartilage regeneration
Abstract
USC scientists have developed a novel surgical strategy to treat cartilage and tendon defects through a polymeric scaffold sheet that can be placed over the lesion to enable regeneration. The composition of the sheet has demonstrated ideal mechanical strength, biostability, barrier, and chemical inertness properties. This novel technology greatly improves upon current techniques, generating a new paradigm for cartilage and tendon treatment.
Benefit
- Scaffold is micromachined into patient's own lesion shape
- Biological factors (growth factors, cytokines, mesenchymal stem cells) can be embedded in and/or absorbed in scaffold to improve healing
- Treatment can be used in combination with regenerative cell therapies and bone marrow stimulating techniques
Market Application
Injured cartilage often results in pain, disability, and in some cases joint degeneration and arthritis. Despite the myriad of surgical treatments for these lesions, current techniques are unsatisfactory due to poor quality of the repaired cartilage, morbidity, cost, availability, long-term outcomes, and survivorship. Therefore, a new method for cartilage and tendon treatment is a necessity.
Publications
Parylene scaffold for cartilage lesion, Biomed Microdevices, June 2017
Other
- Tested on rabbit and mouse models
- Available for exclusive and non-exclusive license