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Antiviral drugs
Effective against Covid-19
Abstract
USC researchers engineered nanoscale barriers capable of lipid interactions with viruses, thus interfering with membrane fusion, and membrane remodeling preventing viral entry and replication. The HPBCD-based platform can safely interact with existing mucocutaneous protective barriers capable of...
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Adhesion of retinal implant
Abstract
USC researchers have identified polymerized N-isopropyl acrylamide (pNIPAM) as a reversible thermosensitive glue for retinal implants. pNIPAM demonstrates strong in vitro retinal adhesion at body temperature, and in vivo tests in rabbits show that pNIPAM exhibits intraoperative retinal adhesion, successfully preventing...
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Diagnostics
Ophthalmology
Abstract
By utilizing an imaging system that includes optical elements and an image sensor array that images the retina and interior eye structures with low light levels that do not cause the pupils to constrict, USC researchers discovered that examinations can be done with naturally dilated pupils. The system collects...
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Diabetic retinopathy
Retinal ischemia
Vascular disease
Abstract
USC researchers have developed a novel method for targeted oxygen therapy for diseases that cause retinal ischemia. Their technique employs an implantable oxygenator with an electrolyte reservoir capable of performing electrolysis, thereby increasing the surrounding oxygen levels....
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Treatment of retinal detachment
Abstract
USC researchers have developed a patch to reattach a detached retina. The device is composed of a polymeric substrate coated on both surfaces with an adhesive compound such that retinal tissue can be re- bonded back to the inner wall of the eye. The patch can be used as an effective and easy-to-use temporary...
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Battlefield wounds
Emergency medical situations and surgeries
Abstract
USC scientists and engineers have developed a reversible temperature-sensitive hydrogel that can seal eye injuries on the spot. The modified gel is liquid at room temperature and transitions to a solid with strong adhesive properties when heated. This seal can be removed simply...
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Chondral, osteochondral, and rotator tendon defect treatment
Rotator cuff tear treatment
Tendon and cartilage regeneration
Abstract
USC scientists have developed a novel surgical strategy to treat cartilage and tendon defects through a polymeric scaffold sheet that can be placed over the lesion to enable regeneration. The composition of the sheet...
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Ophthalmology
Retinal degeneration treatment
Vision and perception research
Abstract
The Argus II retinal implant uses a micro-fabricated electrode array to restore blue-yellow color vision in blind and visually impaired people. The epi-retinal bioelectronic prosthesis is implanted using standard vitreoretinal surgical techniques in as little as...
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Abstract
USC researchers have developed a non-invasive bioelectronic lens (E-lens) system designed to induce epigenetic neuroprotective changes in the retina through controlled electrical stimulation. This system stimulates the retina by delivering safe, controlled electric fields to establish electrical gradients across diseased/degenerating neurons,...
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Restoring vision from retinal degenerative diseases
Abstract
USC researchers have developed a novel ultrasound array to stimulate and image the eyeball. It can be attached to the cornea and worn long-term like a contact lens. By employing ultrasonic features, advanced micro-processing technology, and a sophisticated control algorithm, the device...
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