Description:
- Restoring vision from retinal degenerative diseases
Abstract
USC researchers have developed a novel ultrasound array to stimulate and image the eyeball. It can be attached to the cornea and worn long-term like a contact lens. By employing ultrasonic features, advanced micro-processing technology, and a sophisticated control algorithm, the device could restore vision in those with retinal degenerative diseases by stimulating the retina through the acoustic field. The device initiates pattern reconstruction in ex-vivo murine retinal tissue, and the technique can also be combined with light sources or sonogenetics for maximum control.
Benefit
- Visual prosthesis utilizing a novel ultrasound array
- Ultrasound technology specially designed for the eye
- Restores sight in the visually impaired
- Avoids problems inherent in electronic prostheses
Market Application
There are currently limited treatment options for retinal degenerative diseases such as retinitis pigmentosa and age-related macular degeneration, leading to major visual deficits and blindness. Electronic visual prostheses have emerged as a method to restore vision in those affected, but they also have stoked safety concerns and failed to couple with miniaturized implant units. Ultrasound prostheses could be a viable alternative, as ultrasonic coupling provides accurate control of stimulus charge, has high power limits, and offers enhanced cybersecurity.
Publications
Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses, Jiang et al., 2022.
Other
Stage of Development
- Proof-of-concept demonstrated in ex vivo murine retinal tissue
- Optimization in progress
- Available for licensing