Description:
- Adhesion of retinal implant
Abstract
USC researchers have identified polymerized N-isopropyl acrylamide (pNIPAM) as a reversible thermosensitive glue for retinal implants. pNIPAM demonstrates strong in vitro retinal adhesion at body temperature, and in vivo tests in rabbits show that pNIPAM exhibits intraoperative retinal adhesion, successfully preventing detachment and retinal tears without inducing ocular toxicity or inflammation.
Benefit
- Reliable and reversible adhesion
- Minimized complications
- Optimized implant stability
Market Application
Developing a secure connection between biological and engineered systems remains a key challenge in biomimetics, particularly in microelectronic eye devices. Prior ocular adhesive attempts have produced inflammation, toxicity, weak adhesion, and tissue deformation. A potential solution lies in adaptable polymeric systems that adjust adhesive properties based on physiological changes, enabling reversible tissue adhesion via dynamic stimulus-responsive chemistries. This innovation could revolutionize medical implants and transform the treatment landscape for ocular conditions.
Publications
1. Reversible Thermosensitive Glue for Retinal Implants, Tunc et al., 2007.
2. A Reversible Thermosensitive Adhesive for Retinal Implants: In Vivo Experience with Plasma-Deposited Poly(N-Isopropyl Acrylamide), Tunc et al., 2008.
Other
Stage of Development
- Tested in vitro in pig eyes and in vivo in rabbits
- Available for licensing