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2025-190 - A portable image guided ultrasound stimulator

​​​​​Image-guided ultrasound Wearable stimulator Closed-loop targeting Noninvasive pacing Abstract USC researchers have developed a portable, wearable system intended to support noninvasive cardiac rhythm management using an ultrasound-based approach. The technology is designed to deliver controlled cardiac stimulation without implanted leads...

A programmable ultrasound-induced wireless implantable stimulator for personalized chronic pain management

Wireless Ultrasound-Powered Implant for Personalized Chronic Pain Management Abstract USC researchers have developed a flexible, ultrasound-induced wireless implantable stimulator for personalized chronic pain management. The miniaturized device wirelessly harvests ultrasound energy to deliver programmable electrical stimulation for spinal cord...

Published: 1/17/2026 Inventor(s): Qifa Zhou, Chen Gong, Yushun Zeng
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2022-194 - An Endovascular Electrode Array for Minimally Invasive Recording and Stimulation

Electrical recording and stimulation Management of diseases such as epilepsy Electrophysiological research Abstract USC researchers have developed a thin film electrode array that can be implanted using endovascular methods for minimally-invasive, high-resolution electrical recording and stimulation of the nervous system and other electrogenic...

Published: 12/19/2025 Inventor(s): Ellis Meng, Brianna Thielen
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2018-034 - Means and methods for detecting rhythmic synchronization of motor neuron discharges and their rate variability

EMG technology Supplement to HRV technology Spinal injuries and paralysis, cardiac cases, and muscle injuries Abstract USC researchers have discovered an improved method to analyze the sinusoidal signals induced by the central pattern generator (CPG) in the spine using surface electromyographic (sEMG) activity. The proposed technique identifies...

2020-045 - Single-step Site-specific ?Antibody-Drug Conjugate

Easy method to make antibody-drug conjugates that target specific sites Can be used to kill HER2-expressing breast cancer cells May be used to deliver drugs for other purposes Abstract Researchers at USC developed an innovative class of site-specific ADCs that can be generated in just a single step by coupling proprietary bifunctional antibody...

Published: 12/16/2025 Inventor(s): Yong Zhang, Xiao-Nan Zhang, Zhefu Dai
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2023-010 - High-Speed, Low-Cost, Image Remapping Spectral Domain Full-Field Optical Coherence Tomography

Vision research and diagnosis Intravascular imaging for cardiological stents Esophagus imaging for cancer surveillance Abstract USC researchers have developed a novel full-field OCT approach that increases imaging speed while reducing overall hardware cost by a factor of 5-10. The technique exploits recent developments in additive manufacturing...

Published: 12/16/2025 Inventor(s): Brian Applegate, Tomasz Tkaczyk
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2020-192 - Use of Cyclodextrin Polymers Against Viral Infections

Antiviral drugs Effective against Covid-19 Abstract USC researchers engineered nanoscale barriers capable of lipid interactions with viruses, thus interfering with membrane fusion, and membrane remodeling preventing viral entry and replication. The HPBCD-based platform can safely interact with existing mucocutaneous protective barriers capable of...

2016-230 - Healing Critical-Sized Bone Defects with Gene Therapy & 3D Printed Scaffolds

Orthopedic surgery Bone grafting Abstract USC researchers have developed a technology that combines the use of gene therapy and 3D printed scaffolds. The use of regional gene therapy allows the investigator to incorporate a gene such as a growth factor essential for bone formation. Once at the site, the gene would induce new bone formation. These...

2022-076 - Magnetic Localization for Precision Capsule Endoscopy

Colonoscopy Endoscopic procedures Abstract USC researchers have developed a novel magnetic localization scheme for capsule endoscopy. The method uses frequency-division multiplexing, allowing for reduced coil size and a smaller excitation current. The device contains a fully integrated wireless receiver implemented in 180nm CMOS and contained in...

Published: 2/3/2026 Inventor(s): Constantine Sideris, Michella Rustom
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2019-116 - Focused Ultrasound Transducer with Electrically Controllable Focal Length

Market Opportunity Focused ultrasound (FUS) has a wide application potential in imaging, tumor treatment, neuron stimulation and other areas. Previously designed transducers are of a fixed focal length, with no electrical controllability for focal length, and are incapable of dynamically changing the focal spot without moving the transducer. USC Solution USC...

Published: 2/3/2026 Inventor(s): Eun Kim, Lurui Zhao
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