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Background
Target engagement quantification is crucial in drug discovery for understanding drug-protein interactions, mechanisms of action, and resistance. Traditional methods like activity-based protein profiling with gel fluorescence, while effective, are limited by low throughput, long processing times, and disruption of native protein functions....
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Kidney organoids
Proximal tubule
Nephrotoxicity modeling
Abstract
Kidney organoids have emerged as powerful models to replicate human kidney function, especially focusing on the proximal tubule, a key segment responsible for reabsorption and secretion. Current organoid systems, however, struggle to accurately mimic the complex physiology and injury...
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Background
Many advanced materials and molecular systems require precise, reversible control over molecular interactions. Applications for responsive materials, biomedical systems and adaptive surfaces need on-demand, localized, and reversible control of binding interactions. There is a clear need for small molecule platforms that can be controlled...
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End-to-end spatial proteomics pipeline integrating image correction, cell segmentation, and cell phenotyping
Identifies both common and rare cell populations through semi-supervised clustering for deeper tissue characterization
Generates clinically actionable insights that can predict outcomes such as organ transplant rejection
Abstract
The inventors...
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First scalable human cerebellar organoid platform capable of generating mature, functional Purkinje cells
Recapitulates human cerebellar architecture and cellular diversity for more predictive disease modeling
Enables high-throughput drug screening and therapeutic discovery for neurodevelopmental and neurodegenerative disorders
Abstract
USC researchers...
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Background
Electron paramagnetic resonance (EPR) spectroscopy is an essential tool for detecting and analyzing radicals and substances with unpaired electrons, with applications spanning biomedical diagnostics, materials science, and chemical analysis. However, conventional EPR instruments are constrained by their bulky size, high cost, and substantial...
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Background
Advancements in gene editing have revolutionized biomedical research and therapeutic development, yet current methods lack precise, non-invasive control over gene expression in living organisms. Conventional gene modulation approaches, including chemical inducers and viral vectors, often result in systemic effects, off-target activity, and...
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Background
Natural cellular signaling networks decode dynamic input features such as frequency to produce precise, context-dependent responses, whereas most existing synthetic and optogenetic systems are limited to binary on/off control. This inability to interpret dynamic input states fundamentally constrains the precise and tunable regulation of...
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Scale bars, 5 mm (top left), 1 mm (top right and middle left), and 3 mm (bottom left and right).
Background
The field of biomedical sensing has long faced challenges in achieving reliable monitoring of muscle activity within dynamic tissue environments. Conventional microelectrode arrays and surface electrodes often struggle with mechanical instability,...
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Research tools for identifying various cellular properties
Abstract
USC researchers have generated monoclonal antibodies that recognize and bind to a single epitope on specific antigens for a variety of cells and subcellular properties. Their specificity will ensure more accurate results than their polyclonal counterparts.
Market Application
Visualization...
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