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T-bet promotes apoptosis and regulates ion channels and transporters in intestinal epithelial cells

Brief description Inducible expression of T-bet in epithelial cells promotes apoptosis and can be used as an anti-cancer therapy. Problem Cancer remains a leading cause of mortality worldwide, with epithelial cell cancers such as colon cancer presenting significant treatment challenges. Traditional approaches like chemotherapy and radiation therapy,...

Modulation of chemokine expression for cancer immunotherapy

Background Solid tumors remain largely resistant to T-cell–based immunotherapies due to poor immune cell infiltration within the tumor microenvironment. The absence of key chemokines limits T-cell trafficking, resulting in “cold” tumors that fail to respond to checkpoint inhibitors and adoptive cell therapies. Innovation USC...