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Brief description
Inducible expression of T-bet in epithelial cells promotes apoptosis and can be used as an anti-cancer therapy.
Problem
Cancer remains a leading cause of mortality worldwide, with epithelial cell cancers such as colon cancer presenting significant treatment challenges. Traditional approaches like chemotherapy and radiation therapy,...
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Background
Solid tumors remain largely resistant to T-cell–based immunotherapies due to poor immune cell infiltration within the tumor microenvironment. The absence of key chemokines limits T-cell trafficking, resulting in “cold” tumors that fail to respond to checkpoint inhibitors and adoptive cell therapies.
Innovation
USC...
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Novel protein-based targeted drug delivery strategy
Potential application to treat several ocular disorders
Uses biocompatible, biodegradable and less immunogenic ELP-1 polymers
Abstract
USC scientists genetically engineered elastin-like polypeptides (ELP), which assemble multivalent nanoparticles at physiological temperature. The innovation was...
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Identified Beclin 2 as a critical negative regulator of inflammation and lymphoma development making it and its interacting proteins potential therapeutic targets
Developing novel strategies to modulate Beclin 2 as a method to treat neurodegenerative diseases and cancer which has the potential to be first-in-class
Abstract
USC researchers identified...
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