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Research tools for identifying various cellular properties
Abstract
USC researchers have generated monoclonal antibodies that recognize and bind to a single epitope on specific antigens for a variety of cells and subcellular properties. Their specificity will ensure more accurate results than their polyclonal counterparts.
Market Application
Visualization...
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Research and diagnostic
Flow cytometry
Histopathology
Abstract
A USC researcher has generated a murine monoclonal antibody, 58-15. Since the antibody can be used in paraffin embedded tissue sections, it can identify actively cycling cells within a tissue specimen, making it a useful tool for immunopathologic studies on tissues from which prognostic...
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Genomic research
Cancer research
Abstract
USC researchers present SHARC (Spatial 2'-Hydroxyl Acylation Reversible Crosslinking), a novel tool for RNA structure analysis. SHARC uses chemical crosslinkers to measure nucleotide distances in cellular RNA. With crosslinking, exonuclease trimming, proximity ligation, and high throughput sequencing,...
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Three-finger neurotoxin peptide research
Antibody production
Cell surface receptor synthesis
Abstract
USC researchers have developed a method to produce disulfide bond-rich three-finger toxin peptides using E. Coli as the expression host. The technique encompasses a pipeline for expression, purification, and validation of the proteins. The researchers...
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Replace whole chromosomes and assemble chromosomes into new chromosome architectures
Combine of genetic material from different individuals into chimeric chromosomes
Multiplex deletion of specific genes in a single transformation
Abstract
Our R&D team developed a method to capture segments of natural chromosomes and to then reassemble them...
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Radiolabeled diagnostic tracer for PET imaging/scans
Cancer and cardiovascular imaging
Abstract
Radiolabeled diagnostic tracer for PET imaging/scans
Cancer and cardiovascular imaging
Benefit
Useful for in vivo imaging of tumor and organ tissues (e.g., heart, liver, brain, kidneys
Direct ?uorination method of synthesis is convenient, produces...
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Research tool for vascular and neurodegenerative diseases
Abstract
USC researchers have developed a novel mouse model where pericytes can be identified and depleted in a spatially- and temporally-controlled manner. This ablation has been validated to replicate the cerebrovascular disease and dementia phenotype. Additionally, this model provides...
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Prognostic biomarkers for brain tumors and immunotherapies for glioblastoma multiforme
RNA based biotherapeutics
Abstract
USC researchers have discovered long non-coding RNAs (lncRNAs) that were aberrantly expressed specifically in GBM brains relative to normal brains. These lncRNAs had prognostic significance and could serve as prognostic...
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PET Imaging
Nuclear Medicine
Diagnostics
Abstract
USC researchers were successful in eliminating the bromination process and synthesizing 18F-FMAU using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radio synthesis module, which results...
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Organoids and tissue engineering for applications in regenerative medicine, drug testing, transplantaion, and design of protein rich food sources.
Abstract
USC researchers have developed a system for precise spatial control of gene expression within multicellular constructs. The technology utilizes engineered cells and matrix materials to present...
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