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Background
Electron paramagnetic resonance (EPR) spectroscopy is an essential tool for detecting and analyzing radicals and substances with unpaired electrons, with applications spanning biomedical diagnostics, materials science, and chemical analysis. However, conventional EPR instruments are constrained by their bulky size, high cost, and substantial...
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Background
Advancements in gene editing have revolutionized biomedical research and therapeutic development, yet current methods lack precise, non-invasive control over gene expression in living organisms. Conventional gene modulation approaches, including chemical inducers and viral vectors, often result in systemic effects, off-target activity, and...
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Background
Natural cellular signaling networks decode dynamic input features such as frequency to produce precise, context-dependent responses, whereas most existing synthetic and optogenetic systems are limited to binary on/off control. This inability to interpret dynamic input states fundamentally constrains the precise and tunable regulation of...
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Scale bars, 5 mm (top left), 1 mm (top right and middle left), and 3 mm (bottom left and right).
Background
The field of biomedical sensing has long faced challenges in achieving reliable monitoring of muscle activity within dynamic tissue environments. Conventional microelectrode arrays and surface electrodes often struggle with mechanical instability,...
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Research tools for identifying various cellular properties
Abstract
USC researchers have generated monoclonal antibodies that recognize and bind to a single epitope on specific antigens for a variety of cells and subcellular properties. Their specificity will ensure more accurate results than their polyclonal counterparts.
Market Application
Visualization...
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Research and diagnostic
Flow cytometry
Histopathology
Abstract
A USC researcher has generated a murine monoclonal antibody, 58-15. Since the antibody can be used in paraffin embedded tissue sections, it can identify actively cycling cells within a tissue specimen, making it a useful tool for immunopathologic studies on tissues from which prognostic...
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Genomic research
Cancer research
Abstract
USC researchers present SHARC (Spatial 2'-Hydroxyl Acylation Reversible Crosslinking), a novel tool for RNA structure analysis. SHARC uses chemical crosslinkers to measure nucleotide distances in cellular RNA. With crosslinking, exonuclease trimming, proximity ligation, and high throughput sequencing,...
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Three-finger neurotoxin peptide research
Antibody production
Cell surface receptor synthesis
Abstract
USC researchers have developed a method to produce disulfide bond-rich three-finger toxin peptides using E. Coli as the expression host. The technique encompasses a pipeline for expression, purification, and validation of the proteins. The researchers...
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Replace whole chromosomes and assemble chromosomes into new chromosome architectures
Combine of genetic material from different individuals into chimeric chromosomes
Multiplex deletion of specific genes in a single transformation
Abstract
Our R&D team developed a method to capture segments of natural chromosomes and to then reassemble them...
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Radiolabeled diagnostic tracer for PET imaging/scans
Cancer and cardiovascular imaging
Abstract
Radiolabeled diagnostic tracer for PET imaging/scans
Cancer and cardiovascular imaging
Benefit
Useful for in vivo imaging of tumor and organ tissues (e.g., heart, liver, brain, kidneys
Direct ?uorination method of synthesis is convenient, produces...
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