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Background
Many advanced materials and molecular systems require precise, reversible control over molecular interactions. Applications for responsive materials, biomedical systems and adaptive surfaces need on-demand, localized, and reversible control of binding interactions. There is a clear need for small molecule platforms that can be controlled...
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End-to-end spatial proteomics pipeline integrating image correction, cell segmentation, and cell phenotyping
Identifies both common and rare cell populations through semi-supervised clustering for deeper tissue characterization
Generates clinically actionable insights that can predict outcomes such as organ transplant rejection
Abstract
The inventors...
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First scalable human cerebellar organoid platform capable of generating mature, functional Purkinje cells
Recapitulates human cerebellar architecture and cellular diversity for more predictive disease modeling
Enables high-throughput drug screening and therapeutic discovery for neurodevelopmental and neurodegenerative disorders
Abstract
USC researchers...
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Background
Electron paramagnetic resonance (EPR) spectroscopy is an essential tool for detecting and analyzing radicals and substances with unpaired electrons, with applications spanning biomedical diagnostics, materials science, and chemical analysis. However, conventional EPR instruments are constrained by their bulky size, high cost, and substantial...
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Background
Advancements in gene editing have revolutionized biomedical research and therapeutic development, yet current methods lack precise, non-invasive control over gene expression in living organisms. Conventional gene modulation approaches, including chemical inducers and viral vectors, often result in systemic effects, off-target activity, and...
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Background
Natural cellular signaling networks decode dynamic input features such as frequency to produce precise, context-dependent responses, whereas most existing synthetic and optogenetic systems are limited to binary on/off control. This inability to interpret dynamic input states fundamentally constrains the precise and tunable regulation of...
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Scale bars, 5 mm (top left), 1 mm (top right and middle left), and 3 mm (bottom left and right).
Background
The field of biomedical sensing has long faced challenges in achieving reliable monitoring of muscle activity within dynamic tissue environments. Conventional microelectrode arrays and surface electrodes often struggle with mechanical instability,...
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Research tools for identifying various cellular properties
Abstract
USC researchers have generated monoclonal antibodies that recognize and bind to a single epitope on specific antigens for a variety of cells and subcellular properties. Their specificity will ensure more accurate results than their polyclonal counterparts.
Market Application
Visualization...
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Research and diagnostic
Flow cytometry
Histopathology
Abstract
A USC researcher has generated a murine monoclonal antibody, 58-15. Since the antibody can be used in paraffin embedded tissue sections, it can identify actively cycling cells within a tissue specimen, making it a useful tool for immunopathologic studies on tissues from which prognostic...
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Genomic research
Cancer research
Abstract
USC researchers present SHARC (Spatial 2'-Hydroxyl Acylation Reversible Crosslinking), a novel tool for RNA structure analysis. SHARC uses chemical crosslinkers to measure nucleotide distances in cellular RNA. With crosslinking, exonuclease trimming, proximity ligation, and high throughput sequencing,...
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