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Scale bars, 5 mm (top left), 1 mm (top right and middle left), and 3 mm (bottom left and right).
Background
The field of biomedical sensing has long faced challenges in achieving reliable monitoring of muscle activity within dynamic tissue environments. Conventional microelectrode arrays and surface electrodes often struggle with mechanical instability,...
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Research tools for identifying various cellular properties
Abstract
USC researchers have generated monoclonal antibodies that recognize and bind to a single epitope on specific antigens for a variety of cells and subcellular properties. Their specificity will ensure more accurate results than their polyclonal counterparts.
Market Application
Visualization...
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Research and diagnostic
Flow cytometry
Histopathology
Abstract
A USC researcher has generated a murine monoclonal antibody, 58-15. Since the antibody can be used in paraffin embedded tissue sections, it can identify actively cycling cells within a tissue specimen, making it a useful tool for immunopathologic studies on tissues from which prognostic...
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Genomic research
Cancer research
Abstract
USC researchers present SHARC (Spatial 2'-Hydroxyl Acylation Reversible Crosslinking), a novel tool for RNA structure analysis. SHARC uses chemical crosslinkers to measure nucleotide distances in cellular RNA. With crosslinking, exonuclease trimming, proximity ligation, and high throughput sequencing,...
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Three-finger neurotoxin peptide research
Antibody production
Cell surface receptor synthesis
Abstract
USC researchers have developed a method to produce disulfide bond-rich three-finger toxin peptides using E. Coli as the expression host. The technique encompasses a pipeline for expression, purification, and validation of the proteins. The researchers...
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Replace whole chromosomes and assemble chromosomes into new chromosome architectures
Combine of genetic material from different individuals into chimeric chromosomes
Multiplex deletion of specific genes in a single transformation
Abstract
Our R&D team developed a method to capture segments of natural chromosomes and to then reassemble them...
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Radiolabeled diagnostic tracer for PET imaging/scans
Cancer and cardiovascular imaging
Abstract
Radiolabeled diagnostic tracer for PET imaging/scans
Cancer and cardiovascular imaging
Benefit
Useful for in vivo imaging of tumor and organ tissues (e.g., heart, liver, brain, kidneys
Direct ?uorination method of synthesis is convenient, produces...
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Research tool for vascular and neurodegenerative diseases
Abstract
USC researchers have developed a novel mouse model where pericytes can be identified and depleted in a spatially- and temporally-controlled manner. This ablation has been validated to replicate the cerebrovascular disease and dementia phenotype. Additionally, this model provides...
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Prognostic biomarkers for brain tumors and immunotherapies for glioblastoma multiforme
RNA based biotherapeutics
Abstract
USC researchers have discovered long non-coding RNAs (lncRNAs) that were aberrantly expressed specifically in GBM brains relative to normal brains. These lncRNAs had prognostic significance and could serve as prognostic...
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PET Imaging
Nuclear Medicine
Diagnostics
Abstract
USC researchers were successful in eliminating the bromination process and synthesizing 18F-FMAU using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radio synthesis module, which results...
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