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Biosynthesis of natural products
Elucidating cryptic biosynthesis pathways
Abstract
USC researchers set out to devise a biosynthetic gene clusters (BGC) refactoring strategy and heterologous expression platform in A. nidulans based on the afo regulon. Taking advantage of the transcriptional regulatory elements of afo, the afo genes were replaced...
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Organoids and tissue engineering for applications in regenerative medicine, drug testing, transplantaion, and design of protein rich food sources.
Abstract
USC researchers have developed a system for precise spatial control of gene expression within multicellular constructs. The technology utilizes engineered cells and matrix materials to present...
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Orthopedic surgery
Bone grafting
Abstract
USC researchers have developed a technology that combines the use of gene therapy and 3D printed scaffolds. The use of regional gene therapy allows the investigator to incorporate a gene such as a growth factor essential for bone formation. Once at the site, the gene would induce new bone formation. These...
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Biocatalysis and materials science; Bioremediation
Food Industry
Diagnostics and therapeutics
Abstract
USC researchers employed a maximum entropy (EMaxEnt) approach to accurately predict enzyme catalysis at the active site region, as well as stability at the more distant region. By inferring statistical energy from homologous sequences with the...
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Adhesion of retinal implant
Abstract
USC researchers have identified polymerized N-isopropyl acrylamide (pNIPAM) as a reversible thermosensitive glue for retinal implants. pNIPAM demonstrates strong in vitro retinal adhesion at body temperature, and in vivo tests in rabbits show that pNIPAM exhibits intraoperative retinal adhesion, successfully preventing...
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Treatment of retinal detachment
Abstract
USC researchers have developed a patch to reattach a detached retina. The device is composed of a polymeric substrate coated on both surfaces with an adhesive compound such that retinal tissue can be re- bonded back to the inner wall of the eye. The patch can be used as an effective and easy-to-use temporary...
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Battlefield wounds
Emergency medical situations and surgeries
Abstract
USC scientists and engineers have developed a reversible temperature-sensitive hydrogel that can seal eye injuries on the spot. The modified gel is liquid at room temperature and transitions to a solid with strong adhesive properties when heated. This seal can be removed simply...
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Wastewater treatment for high levels of organic matter, including for dairy farms, cattle feed lots, food processing, pulp and paper mills, and petrochemicals
Abstract
USC researchers have developed a novel approach to wastewater treatment by employing a layered structure with microorganisms and granular activated carbon enhanced with graphene oxide....
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Chondral, osteochondral, and rotator tendon defect treatment
Rotator cuff tear treatment
Tendon and cartilage regeneration
Abstract
USC scientists have developed a novel surgical strategy to treat cartilage and tendon defects through a polymeric scaffold sheet that can be placed over the lesion to enable regeneration. The composition of the sheet...
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Composite manufacturing
Abstract
USC researchers have developed a hybrid human-robot cell to streamline the labor-intensive multi-layer prepreg composite sheet layup process. Human experts initially assess and provide high-level commands, which the system translates into safe trajectories for the robots. The feasibility of using robotic manipulators...
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