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Market Opportunity
Structure-based virtual ligand screening is emerging as a key paradigm for early drug discovery owing to the availability of high-resolution target structures and ultra-large libraries of virtual compounds. However, to keep pace with the explosive growth of virtual chemical libraries, new approaches to compound screening are needed.
USC...
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Improves the efficacy of current immunotherapies by individually targeting T cell receptors proteins
Creates a therapy that boasts a higher chance of survival compared to the standard of care for acute myeloid leukemia
Abstract
USC researchers created genetically engineered exosomes (SMART-Exos) that display two distinct monoclonal antibodies targeting...
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Cancer treatment
Abstract
USC researchers have developed a technique for optimizing CAR-T and CAR-NK cell specificity that employs human leukocyte antigen DR (HLA-DR) downregulation in malignant cells. Because malignant cancer cells generally express HLA-DR at lower levels than healthy cells, CAR-NK cells inhibited against HLA-DR will preferentially...
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Antibacterial therapeutic
Abstract
USC researchers engineered novel cyclotide with effective broad-spectrum antibacterial activity against several ESKAPE bacterial strains and clinical isolates. Cyclotides are micro-proteins (˜30 residues long) that have shown remarkable stability, are easily synthesized and have shown good oral bioavailability....
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Deliver drugs for cancer and other diseases
Abstract
Using a newly discovered NAD+ analogue with excellent activity for poly-ADP-ribosylation, functionalized poly-ADP-ribose polymers were robustly synthesized. The functionalized poly-ADP-ribose polymers provide a novel type of drug carrier that allows for facile conjugation of monoclonal antibodies...
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Therapeutic peptide targets RAS signal transduction pathways, and can be utilized for indications associated with these pathways
Abstract
USC researchers have discovered that the novel oral formulation of Nle3-A(1-7) has the unexpected result that shows significantly more potent therapeutic effects than corresponding compositions. This oral formulation...
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Biopsy-based diagnostic platform for determining subtype and malignancy of renal cancers
Abstract
USC scientists have built a predictive cancer classification model using 697 DNA methylation profiles that can distinguish between six different sub-types of kidney tumors. They have validated the DNA methylation dependent classifier in 272 ex-vivo needle...
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Colorectal cancer treatment
Abstract
Our R&D team developed a cell-permeable Hdm2/HdmX E3 ligase inhibitor that shows in vitro activity in many cancer cell-lines (prostate carcinoma, osteosarcoma, lung carcinoma, colon carcinoma and ovarian carcinoma, among others) with p53 wt, mutated or null. This compound has shown activity in a colorectal...
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Targeted cancer immunotherapy
Biomedical research
Pharmacological innovation
Abstract
USC researchers have developed a novel approach using PAR polymers for the synthesis of bispecific antibodies, targeting both HER2 and T-cell CD3 antigens. By conjugating anti-HER2 and anti-CD3 monoclonal antibodies to azido-functionalized PAR polymers, researchers...
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Therapeutic delivery
Biomedical research
Drug development
Abstract
USC researchers have generated PAR polymers with high therapeutic potential. They synthesized PAR polymers conjugated with human granulocyte colony-stimulating factor (GCSF) protein using auto-poly- ADP-ribosylation. The resulting PAR polymer-based conjugate, with multivalent GCSF...
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